Michelle Nina Arbeitman
Assistant Professor of Biological Sciences
Phone: (213) 740-3653
Molecular and Computational Biology
- BA, Molecular Cell Biology, University of California, Berkeley
- Ph.D., Developmental Biology, Stanford University
- Postdoctoral Fellow, Stanford University
- Sex determination
Research OverviewOur work focuses on two questions at a genome wide level: (1) how is the sex-specific potential for courtship behavior built into the nervous system- and (2) how does the sex-specific deployment of a regulatory hierarchy act on a molecular level to generate and maintain aspects of sex-specific differences in adults?
In Drosophila, all aspects of sexual differentiation are under the control of the sex determination hierarchy. Using microarray tools to analyze mutants in the sex determination hierarchy, we have identified many new genes controlled by the sex hierarchy.
We have identified genes that are required in the nervous system for male courtship behavior and those required for the development and maintenance of adult sex-specific differences.
The identification of these genes using microarray approaches has provided insight into how gene networks are established on a genomic level.
Ongoing research in the lab includes additional genomic and computational analyses of the sex hierarchy. We are also performing functional studies of the genes identified that play a role in courtship behaviors, to understand how complex behaviors are specified at a molecular level.
Dalton, J., Lebo, MS., Sanders, LE., Sun, F. and Arbeitman, MN. (2009) Ecdysone receptor acts in fruitless-expressing neurons to mediate Drosophila courtship behaviors. In press Current Biology.
Tower, J. and Arbeitman, MN. (2009) The genetics of gender and life span. J Biol. 2009;8(4):38. -PubMed
Lebo, MS., Sanders, LE., Sun, F. and Arbeitman, MN. (2009) Somatic, Germline and Sex Hierarchy Regulated Gene Expression During Drosophila Metamorphosis. BMC Genomics, 10(80). -PubMed
Sanders, LE. and Arbeitman, M.N. (2008) Doublesex establishes sexual dimorphism in the Drosophila central nervous system in an isoform dependent manner by directing cell number Developmental Biology. 320(2): 378-90. -PubMed
Goldman, T.D., and Arbeitman, M.N. (2007) Genomic and Functional Analyses of Drosophila Sex Hierarchy Regulated Gene Expression in Adult Head and Central Nervous System Tissues. (2007) Plos Genetics. 3(11):e216. -PubMed